コロナ鬱とは何か

過労や強いストレスが、なぜうつ病を引き起こすのか。この謎の答えの鍵を握るウイルス由来のたんぱく質を、東京慈恵会医大の研究チームが確認した。このたんぱく質はうつ病の発症リスクを大幅に高めるといい、このたんぱく質の存在が確認された人は、そうでない人に比べ12・2倍うつ病になりやすかった。

慈恵医大の近藤一博教授(ウイルス学)らは長年、疲労とウイルスの関係を調べ、疲労が蓄積すると唾液(だえき)中に「ヒトヘルペスウイルス(HHV)6」が急増することを突き止めていた。

HHV6は、赤ちゃんの病気である突発性発疹の原因ウイルスで、ほぼ全ての人が乳幼児期に感染し、以降ずっと、体内に潜伏感染している。

普段は休眠しているが、体が疲れると、HHV6は目覚め「弱った宿主から逃げだそう」と、唾液中に出てくる。その一部が口から鼻へ逆流する形で、においを感じる脳の中枢「嗅球(きゅうきゅう)」に到達し、再感染を起こしていた。

近藤教授らは、再感染すると、嗅球で「SITH(シス)1(ワン)」というたんぱく質が作られ、この働きで脳細胞にカルシウムが過剰に流れ込み、死んでいくことを培養細胞やマウスの実験で突き止めた。さらに、嗅球の細胞死によって、記憶をつかさどる海馬での神経再生が抑制されていた。

計166人の血液で、このたんぱく質があることの証明になる「抗体」を調べると、うつ病患者の8割で確認され、量も健常人に比べ、うつ病患者で極めて多かった。

研究チームは、過労やストレスからうつ病が発症する経緯を①過労などでHHV6が唾液に出る②嗅球に再感染し、SITH1を作る③SITH1によって嗅球や海馬などで脳細胞の状態が激変する④意欲減退などが起きる――という流れではないかと推論している。

近藤教授は「過労がうつ病につながるということは当たり前のようで、実はこれまで立証されていなかった。発症の仕組みの一端が見えたことで、うつ病の本態の解明につながれば」と話す。

シスー1のシスは「スターウォーズに登場する悪役・暗黒郷の名前にちなんで」名づけられている。ウィルスの遺伝子が鬱病の要因である。

新型コロナウィルスも鬱病の要因となる。米国医師会雑誌ジャーマに論文が掲載される。

湖北省の住民対象で56932人にオンラインアンケートを実施する。回答率は79・9%。回答者の平均年齢は35・97歳。回答者の69・6%が18歳から39歳。男性が47・9%。

鬱病・不眠・不安・急性ストレス反応のリスクが高かったのは新型コロナ陽性患者・感染を疑われた者・その家族・友人、濃厚接触者である。
回答者全体の中で、鬱病が27・9%、不安が31・6%、不眠が29・2%、急性ストレス反応が24・4%。

治療の為、寮・コンベンションセンター・学校へ隔離されている人、職場復帰が遅れている人にも高リスクで鬱症状が見られた。

研究期間は2月28日から3月11日まで。アンケート回答者の93・2%は都市部に住んでいる。77・2%が既婚者。83・2%が大学卒業者。

鬱病・不安・不眠・急性ストレス反応の、31・0%の家族・友人が新型コロナ患者と接する仕事に従事しており、29・0%が隔離を経験した、34・9%が仕事復帰出来ていない。
鬱病・不安・不眠・急性ストレス反応の生活要因は、40歳より若い、低収入、精神疾患の履歴が有る等。未婚の男性が高リスクだった。若者で一人で暮らす者が高リスクだった。

陽性患者で体に痛みが有る者、薬の副作用で苦しむ者に鬱・不眠・急性ストレス反応のリスクが高かった。

陽性患者の家族も、自身が感染する鬱状態・不安に苛まれ、周囲からの差別・偏見に傷つけられ苦しむ。
感染に対する恐怖・感染蔓延が精神的打撃となる。感染蔓延が強いストレスを与える。感染蔓延地域に住む人が高リスクである。

最前線で働く医療者は必ずしも鬱や不安に陥らない。自身が感染するリスクに気が付いている。感染リスクに対処する心構え・感染リスクに順応する高いスキルの生活方法・支援を受ける方策を持っている、訓練されている。

情報が多すぎてかく乱されるストレスも高リスクだ。若者の方がソーシャルメディアに触れる機会が多い。ネット上の誤った新型コロナ情報が精神的な問題の引き金を引く危険性が高い。

職場で会話することが鬱病のリスクを和らげる。在宅勤務テレワーク・リモートワークは精神衛生に良くない。家庭内の人間関係にストレスを持つ。職場復帰が遅れることが危険である。

隔離は大人にも子供にも強いストレスを与える。学校の一斉休校が子供に精神的悪影響を与える。

ホリエモン・小林よしのり・藤井聡・宮沢孝幸「コロナで死ななくても、不景気で自殺者が出る。」の一点張りである。粗雑な論でゴーツートラベルに政治利用される論である。正確に言えば「経済格差の固定による鬱病で絶望死に至る」である。

新型コロナウィルスもメンタルを攻撃する。陽性患者・感染を疑われた者・家族・友人・濃厚接触者が鬱病を発症し、絶望死する危険性も高い。

「経済を回せ」論者は医学と経済学を学び直すのが良い。米格付け会社ムーディーズは27日、英航空機エンジン大手ロールス・ロイス<RR.L>の長期格付け(シニア、無担保)を投機的等級に引き下げた。取引先である航空業界の業績が低迷しており、今後さらに悪化する恐れがあるとしている。 Baa3からBa2に2段階引き下げた。格付け見通しは「ネガティブ」。 伝統のブランドの格が下がるのも世界金融バブル崩壊の足音である。

今回の金融バブル崩壊はブラックスワンではなく、ドラゴンキングである。バブルを散々膨らませた挙句、世界恐慌レベルの大崩壊を引き起こす。

後、しばらくすれば、大恐慌が襲来し経済格差の固定化による絶望死が減る可能性が高い。全員が等しく貧しくなる。支え合って助け合って生きてゆく、相互扶助の温かい社会を取り戻せるかもしれない。

今、闇雲に「経済を回せ」と叫ぶのは暴論である。先ずは安倍政権・政府に感染症対策の徹底を要求すべきである。

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